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1

Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase

Randall C. Willis, L. Dee Nord, James M. Fujitaki, Roland K. Robins

Journal:

Advances in Enzyme Regulation

Year:

1989

Language:

english

File:

PDF, 860 KB

english, 1989

2

Cyclization of nucleotide analogues as an obstacle to polymerization

Aubrey R. Hill, L. Dee Nord, Leslie E. Orgel, Roland K. Robins

Journal:

Journal of Molecular Evolution

Year:

1988-1989

Language:

english

File:

PDF, 140 KB

english, 1988-1989

3

Synthesis of certain pyrazolo[3,4-d]pyrimidin-3-one nucleosides

Jack D. Anderson, Howard B. Cottam, Steven B. Larson, L. Dee Nord, Ganapathi R. Revankar, Roland K. Robins

Journal:

Journal of Heterocyclic Chemistry

Year:

1990

File:

PDF, 1004 KB

1990

4

Inhibition of orotidylate decarboxylase by 4(5H)-oxo-1-β-d-ribofuranosylpyrazolo[3,4-d] pyrimidine-3-thiocarboxamide (APR-TC) in B lymphoblasts: Activation by adenosine kinase

L. Dee Nord, Randall C. Willis, Donald F. Smee, Timothy A. Riley, Ganapathi R. Revankar, Roland K. Robins

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 881 KB

english, 1988

5

Inhibition of phosphoribosylpyrophosphate synthetase by 4-methoxy-(MRPP) and 4-amino-8-(d-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (ARPP)

L. Dee Nord, Randall C. Willis, Timothy S. Breen, Thomas L. Avery, Rick A. Finch, Yogesh S. Sanghvi, Ganapathi R. Revankar, Roland K. Robins

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 969 KB

english, 1989

6

Inhibition of pyrimidine metabolism in myeloid leukemia cells by triazole and pyrazole nucleosides

Steven S. Matsumoto, James M. Fujihaki, L.Dee Nord, Randall C. Willis, Vincent M. Lee, Brahma S. Sharma, Yogesh S. Sanghvi, Ganesh D. Kini, Ganapathi R. Revankar, Roland K. Robins, Weldon B. Jolley, R

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 861 KB

english, 1990

7

Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA

L.Dee Nord, Daniel S. Martin

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 995 KB

english, 1991

8

Biochemical modulation of 5-fluorouracil with leucovorin or delayed uridine rescue: Correlation of antitumor activity with dosage and fUra incorporation into RNA

L.Dee Nord, Robert L. Stolfi, Daniel S. Martin

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 816 KB

english, 1992

9

Biochemical modulation of tumor cell energy IV: Evidence for the contribution of adenosine triphosphate (ATP) depletion to chemotherapeutically-induced tumor regression

Joseph R. Colofiore, Robert L. Stolfi, L. Dee Nord, Daniel S. Martin

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 749 KB

english, 1995

10

Correlation of retention of tumor methylmercaptopurine riboside-5′phosphate with effectiveness in CD8F1 murine mammary tumor regression

L. Dee Nord, Robert L. Stolfi, Joseph R. Colofiore, Daniel S. Martin

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 865 KB

english, 1996

11

Antitumor and antiviral activity of synthetic .alpha.- and .beta.-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides

Sanghvi, Yogesh S., Larson, Steven B., Matsumoto, Steven S., Nord, L. Dee, Smee, Donald F., Willis, Randall C., Avery, Thomas L., Robins, Roland K., Revankar, Ganapathi R.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.25 MB

english, 1989

12

Structural Mimicry of Adenosine by the Antitumor Agents 4-methoxy- and 4-amino-8-(β -D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine as Viewed by a Molecular Modeling Method

Arup K. Ghose, Vellarkad N. Viswanadhan, Yogesh S. Sanghvi, L. Dee Nord, Randall C. Willis, Ganapathi R. Revankar and Roland K. Robins

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.46 MB

english, 1989

13

Synthesis, structure, and biological activity of certain 2-deoxy-.beta.-D-ribo-hexopyranosyl nucleosides and nucleotides

Nord, L. Dee, Dalley, N. Kent, McKernan, Patricia A., Robins, Roland K.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.59 MB

english, 1987

14

Synthesis and intramolecular hydrogen bonding and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside

Moss, Randall J., Petrie, Charles R., Meyer, Rich B., Nord, L. Dee, Willis, Randall C., Smith, Roberts A., Larson, Steven B., Kini, Ganesh D., Robins, Roland K.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 689 KB

english, 1988

15

Biochemical Modulation of Tumor Cell Energy in Vivo: II. A Lower Dose of Adriamycin is Required and a Greater Antitumor Activity is Induced when Cellular Energy is Depressed

Martin, Daniel S., Stolfi, Robert L., Colofiore, Joseph R., Nord, L. Dee, Sternberg, Stephen

Journal:

Cancer Investigation

Year:

1994

Language:

english

File:

PDF, 2.09 MB

english, 1994

16

Enhancement of thymidylate synthase inhibition

Nord, L. Dee, Martin, Daniel S.

Journal:

Current Opinion in Oncology

Year:

1993

File:

PDF, 551 KB

1993

17

Marked enhancement in vivo of paclitaxel??s (taxol??s) tumor-regressing activity by ATP-depleting modulation

Martin, Daniel S, Stolfi, Robert L, Colofiore, Joseph R, Nord, L Dee

Journal:

Anti-Cancer Drugs

Year:

1996

File:

PDF, 392 KB

1996